Association of KISS1 Gene SNPs (rs12998) With Endocrine Parameters in Iraqi women Polycystic Ovary Syndrome
نویسندگان
چکیده
background: (PCOS) is among the most common types of gynecological hormonal abnormalities and metabolic problems that have an impact females throughout adolescence, with a prevalence 6-10%.Hyperandrogenism, unreliable menstrual periods, polycystic ovaries are hallmarks PCOS. The (HPG) axis controlled by kisspeptins, peptides made KISS1 gene.Objectives: This investigation's objective about used to be analyze affiliation kiss1 Gene SNPs (rs 12998 ) Endocrine Parameters in PCOS .Methodology: A case -control find out enrolled one hundred sixty members which eighty female symbolize manage crew who had-been interestingly healthful. Patients had been chosen patients from our health center teaching hospital's gynecology obstetrics department Tikrit. Assessment serum ( kisspeptin, estradiol ,LH, FSH testosterone) performed use ELISA approach maker company's provided methodology was followed extract genomic DNA whole blood. rs12998 T>C gene polymorphisms once detected using (T-ARMS-PCR) method.Results: Findings indicate, frequency CT TT genotypes PCOS-affected women increased 1.63-fold 8.88-fold comparison group healthy odds ratio (OR); 1.63 8.88, 95% [CI], 0.667-3.988 2.014-39.222; p-value 0.28 & 0.01**), respectively. levels Kisspeptin, LH, testosterone also differ.Conclusions: Our suggests greater awareness Kisspeptin were observed as contrast well, homozygous allele (CC) patient 15 than controls 3 whilst heterozygous (CT) now not drastically distinct fifty six much less allelic SNP C/T extra regularly significant
منابع مشابه
Serum Leptin and Ghrelin Levels in Women with Polycystic Ovary Syndrome: Correlation with Anthropometric,Metabolic, and Endocrine Parameters
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Negative Results
سال: 2022
ISSN: ['0976-9234', '2229-7723']
DOI: https://doi.org/10.47750/pnr.2022.13.s06.065